«Conversations with Giants in Medicine»: A conversation with Bert Vogelstein and Ken Kinzler

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«Conversations with Giants in Medicine»: A conversation with Bert Vogelstein and Ken Kinzler

Wednesday, 08.06.2016

Every year, millions of people are diagnosed with cancer, and much of what we know about the genetics of cancer comes from the work of two legendary scientists, Bert Vogelstein, MD, and Ken Kinzler, PhD, which are co-directors of the Ludwig Center at the Sidney Kimmel Comprehensive Cancer Center of the Johns Hopkins University School of Medicine.

 

Vogelstein and Kinzler demonstrated that colorectal cancer results from the sequential accumulation of mutations in oncogenes and tumor suppressor genes, establishing a paradigm for modern cancer genomics. Additionally, they discovered the tumor suppressors APC and TP53; they were the first to perform exomic sequencing in tumors; and they developed digital PCR.

 

In an interview with JCI’s Editor, Ushma Neill, Vogelstein and Kinzler reflect on their career trajectories and past discoveries and discuss their goals as scientists.

 

You can see more here: http://www.jci.org/posts/475