Modulating Autophagy as a Therapeutic Strategy for the Treatment of Paediatric High Grade Glioma

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Modulating Autophagy as a Therapeutic Strategy for the Treatment of Paediatric High Grade Glioma

Friday, 03.05.2019

Authors and Affiliations:

Howarth A1, Madureira PA1,2, Lockwood G3, Storer LCD3, Grundy R3, Rahman R3, Pilkington GJ1, Hill R1.

1 Brain Tumour Research Centre, Institute of Biomedical and Biomolecular Sciences, IBBS, University of Portsmouth, PO1 2DT, UK

2 Centre for Biomedical Research (CBMR), University of Algarve, Campus of Gambelas, Building 8, Room 3.4, 8005-139 Faro, Portugal

3 Children’s Brain Tumour Research Centre, School of Medicine, Queen's Medical Centre, University of Nottingham, NG7 2UH, UK

 

Abstract:

Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated in pHGG, promoting tumour progression and evading cell death. There is significant cross talk between autophagy and a plethora of critical cellular pathways, many of which are dysregulated in pHGG.

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The following article will discuss our current understanding of autophagy signalling in pHGG and the potential modulation of this network as a therapeutic target.

 

Financiamento: A.H. foi financiada por uma bolsa de doutoramento da Fundação Ollie Young, ref: 1148511. P.A.M. é financiada por um contrato Investigador FCT da Fundação para a Ciência e a Tecnologia (FCT), Portugal, ref:IF/00614/2014, e um projeto exploratório da FCT, ref:IF/00614/2014/CP12340006. G.J.P foi financiado pelas Fundações Ollie Young e Brain Tumour Research. R.H. é financiado pela Fundação Brain Tumour Research. O Centro de Investigação em Biomedicina (Centre for Biomedical Research, CBMR) da Universidade do Algarve é financiado pela FCT, ref:UID/BIM/04773/2013CBMR1334.

 

Journal: Brain Pathology

 

Link: https://onlinelibrary.wiley.com/doi/epdf/10.1111/bpa.12729