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Goodbye Flat Biology: Next Generation Cancer Models

EACR-ESOI Joint Conference: Imaging Cancer: Gaining insights from cells to organisms

EACR-ESOI Joint Conference: Imaging Cancer: Gaining insights from cells to organisms

Bioinformatics in Cancer

Bioinformatics in Cancer

A novel in vitro Ewing's Sarcoma 3D cell model

Autores e Afiliações:

Giacomo Domenici 1,2 Rodrigo Eduardo 1,2 Helena Castillo-Ecija 3 Gorka Orive 4,5 Ángel Montero Carcaboso 3 Catarina Brito 1,2

1-iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2781-901 Oeiras, Portugal

2-Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal

A novel in vitro Ewing's Sarcoma 3D cell model

Ewing’s Sarcoma (ES) is the second most frequent bone tumour in children and young adults, with very aggressive behaviour and significant disease recurrence. To better study the disease and find new therapies, experimental models are needed. In this work, we developed a novel ES cell culture method based on 3D spheroids. Our culture method maintains cell viability and ES intrinsic characteristics preservation for at least one month, allowing ex-vivo testing of anticancer drugs.

 

Unveiling the mechanism of action behind the anti-cancer properties of cannabinoids in ER+ breast cancer cells: Impact on aromatase and steroid receptors

Authors and Affiliations:

Cristina Amaral, Fabien Marc Trouille, Cristina Ferreira Almeida, Georgina Correia-da-Silva, Natércia Teixeira

UCIBIO.REQUIMTE, Laboratório de Bioquímica, Faculdade de Farmácia, Universidade do Porto

 

Abstract:

Unveiling the mechanism of action behind the anti-cancer properties of cannabinoids in ER+ breast cancer cells: Impact on aromatase and steroid receptors

Autores e Afiliações:

Cristina Amaral, Fabien Marc Trouille, Cristina Ferreira Almeida, Georgina Correia-da-Silva, Natércia Teixeira

UCIBIO.REQUIMTE, Laboratório de Bioquímica, Faculdade de Farmácia, Universidade do Porto

 

Abstract:

Healthcare use and costs in early breast cancer

Breast cancer is a heterogeneous disease, composed of different subtypes. However, there are no real-world data on the cost of treatment according to these different subtypes. This study aimed to estimate the direct medical costs of diagnosing and treating early breast cancer in the first 3 years after diagnosis according to subtype and stage.

We included 703 women with early breast cancer, newly diagnosed, admitted in 2012 to the Portuguese Institute of Oncology in Porto, who were prospectively followed in the NEON-BC cohort.