gastric cancer

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Probing the O-glycoproteome of Gastric Cancer Cell Lines for Biomarker Discovery

Authors and Affiliations:

Diana Campos1,2, Daniela Freitas2, Joana Gomes2, Ana Magalhães2, Catharina Steentoft1, Catarina Gomes2, Malene B. Vester-Christensen1*, José Alexandre Ferreira3,4, Luis P. Afonso5, Lúcio L. Santos3, João Pinto de Sousa6, Ulla Mandel1, Henrik Clausen1, Sergey Y. Vakhrushev1, Celso A. Reis2,6,7

Worldwide Burden of Gastric Cancer Attributable to Tobacco


Bárbara Peleteiro1,2, Clara Castro1,3, Samantha Morais1, Ana Ferro1, Nuno Lunet1,2 1 EPIUnit – Institute of Public Health, University of Porto, Porto, Portugal 2 Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal 3 North Region Cancer Registry (RORENO) – Portuguese Oncology Institute, Porto, Portugal

Familial gastric cancer: genetic susceptibility, pathology, and implications for management

Authors and Affiliations:

Carla Oliveira*, Hugo Pinheiro*, Joana Figueiredo, Raquel Seruca, Fátima Carneiro

Ipatimup-Institute of Molecular Pathology and Immunology & Instituto Instituto de Investigação e Inovação em Saúde,

(C Oliveira PhD, H Pinheiro PhD, J Figueiredo PhD, R Seruca MD, Prof F Carneiro MD), and

Department of Pathology and Oncology, Faculty of Medicine (C Oliveira, R Seruca, F Carneiro),

University of Porto, Porto, Portugal; and Centro Hospitalar S João, Porto, Portugal (F Carneiro)

 

Familial gastric cancer: genetic susceptibility, pathology, and implications for management

Autores e Afiliações:

Carla Oliveira*, Hugo Pinheiro*, Joana Figueiredo, Raquel Seruca, Fátima Carneiro

Ipatimup-Institute of Molecular Pathology and Immunology & Instituto Instituto de Investigação e Inovação em Saúde,

(C Oliveira PhD, H Pinheiro PhD, J Figueiredo PhD, R Seruca MD, Prof F Carneiro MD), and

Department of Pathology and Oncology, Faculty of Medicine (C Oliveira, R Seruca, F Carneiro),

University of Porto, Porto, Portugal; and Centro Hospitalar S João, Porto, Portugal (F Carneiro)

 

Causes and consequences of microsatellite instability in gastric carcinogenesis

This review summarizes the current knowledge on the molecular mechanisms underlying the acquisition of microsatellite instability (MSI) in gastric cancer (GC) as well as on the clinic, pathologic and molecular consequences of the MSI phenotype. Additionally, current therapeutic strategies for GC and their applicability in the MSI subset are also discussed.

 

Authors and Affiliations:

Sérgia Velho*, Maria Sofia Fernandes*, Marina Leite, Ceu Figueiredo, Raquel Seruca
 * authors contributed equally to this paper

Causas e consequências da instabilidade de microsatélites na carcinogénese gástrica

Este artigo de revisão sumariza o conhecimento atual acerca dos mecanismos moleculares subjacentes à aquisição da instabilidade de microsatélites (MSI) no cancro gástrico (GC), bem como nas consequências clínicas, patológicas e moleculares do fenótipo MSI. Também são discutidas as estratégias terapêuticas no GC, e o seu potencial benefício em pacientes com fenótipo MSI.

 

Autores e Afiliações:

Sérgia Velho*, Maria Sofia Fernandes*, Marina Leite, Ceu Figueiredo, Raquel Seruca
 * authors contributed equally to this paper

New method of diagnosis of stomach cancer

 

 

Authors and Affiliations:

João Miguel Sanches1, Joana Figueiredo2, Martina Fonseca1, Cecília Durães2, Soraia Melo2, Sofia Esménio1 and Raquel Seruca 2,3

1Institute for Systems and Robotics and Department of Bioengineering from the Instituto Superior Técnico, Technical University of Lisbon, Lisbon, Portugal

Modified-Chitosan/siRNA Nanoparticles Downregulate Cellular CDX2 Expression and Cross the Gastric Mucus Barrier

Authors and Affiliations:

Ana Sadio 1,2,3,4,5, Jenny K. Gustafsson 6, Bruno Pereira 1, Carla Pereira Gomes 2,7, Gunnar C. Hansson 6, Leonor David 1,5, Ana Paula Pêgo 2,7,8, Raquel Almeida 1,5*

1 IPATIMUP- Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal,

2 INEB – Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal,

Gastric cancer mortality, predictions and incidence by subtype


Ana Ferro 1, Bárbara Peleteiro 1,2, Matteo Malvezzi 3, Cristina Bosetti 3, Paola Bertuccio 3, Fabio Levi 4, Eva Negri 3, Carlo La Vecchia 3,5 , Nuno Lunet 1,3 1-Institute of Public Health of the University of Porto (ISPUP), Rua das Taipas nº 135, 4050-600 Porto, Portugal

2-Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

Genetic variants in the interleukin 1 alpha (IL1A) gene are associated with gastric cancer

This study is part of the EUR-GAST Project, established to elucidate the effects of Helicobacter pylori infection, genetic polymorphisms and environmental factors in gastric cancer etiology in European populations. The EUR-GAST Project is enclosed in a much larger European investigation (European Prospective Investigation into Cancer and Nutrition – EPIC) which is designed to investigate the relationships between diet, nutritional status, lifestyle and environmental factors and the incidence of cancer and other chronic diseases.