HPV infection

In the last years, the research team of Ângela Sousa has been focused on the development of biotechnological strategies with therapeutic potential for cervical cancer treatment. The development of this disease is strongly associated with infection by Human Papillomavirus (HPV), being the latter responsible for the production of E6 and E7 oncoproteins. These proteins have the ability of interfering with cellular regulatory mechanisms fueled by tumor suppressor proteins, such as p53 and pRB proteins.

Nos últimos anos, a equipa de investigação de Ângela Sousa tem-se focado no desenvolvimento de estratégias biotecnológicas com potencial terapêutico no tratamento de cancro do colo do útero. O desenvolvimento desta doença está fortemente associado à infeção pelo Vírus do Papiloma Humano (HPV), sendo que este último é responsável pela produção das oncoproteínas E6 e E7.

Authors and Affiliations:

Joana Ribeiro,^1,2,3 Joana Marinho Dias,^1,2,4 Paula Monteiro,⁵ Joana Loureiro,⁵ Inês Baldaque,¹ Rui Medeiros,^1,2,4,6 and Hugo Sousa ^1,2

¹ Virology Service, Portuguese Institute of Oncology of Porto, Portugal

² Molecular Oncology and Viral Pathology Group (CI-IPOP), Portuguese Institute of Oncology of Porto