Treatment and management of breast cancer imposes a heavy burden on the public health care. However, in spite of the considerable advancements in the treatment of this malignancy in the recent years, many patients continue to progress to metastatic disease and, for those with advanced breast cancer, palliative care is oftentimes the endpoint. The manifestation of metastases is predictive of poor clinical outcome, and prevails one of the most challenging issues faced by cancer treatment today.
