Cancer Genetics

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i3S lidera estudo que redefine o risco de cancro e as diretrizes de testes para portadores do gene CTNNA1

Um estudo internacional envolvendo 56 investigadores e clínicos de nove países, liderado pela cientista Carla Oliveira, do Instituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S), e publicado na prestigiada revista GUT, definiu novas causas de risco genético de cancro gástrico e mamário e critérios clínicos para os identificar.

Landmark Study Redefines Cancer Risk and Testing Guidelines for CTNNA1 Gene Carriers

A groundbreaking international study has provided critical insights into the role of CTNNA1 gene variants in hereditary diffuse gastric cancer (HDGC), revealing new associations with cancer risk and paving the way for improved genetic testing and clinical management of affected individuals.

The study involved 56 researchers and clinicians from 9 countries, from the European and American continents, led by an i3S team in Porto.

Animal Models of Cancer Conference

Animal Models of Cancer Conference

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

Authors and affiliations:

Bruno Silva(1), Richard Pentz(1), Ana Margarida Figueira(1), Rajika Arora(1), Yong Woo Lee(1), Charlotte Hodson(2), Harry Wischnewski(3), Andrew J. Deans(2,4), and Claus M. Azzalin(1)

(1)Instituto de Medicina Molecular João Lobo Antunes (iMM), Faculdade de Medicina da Universidade de Lisboa, Lisbon, 1649-028, Portugal

(2)Genome Stability Unit, St. Vincent’s Institute of Medical Research, Fitzroy, 3065, VIC, Australia

Novo estudo revela um mecanismo de sobrevivência inesperado de um subconjunto de células tumorais

Os tumores ALT compreendem aproximadamente 10% dos tumores humanos, desenvolvem-se maioritariamente em crianças (por exemplo, o osteossarcoma juvenil) e são particularmente resistentes à quimioterapia convencional. «Ao contrário do mecanismo canónico de alongamento dos telómeros, que ativa a enzima telomerase, essas células tumorais usam especificamente esse caminho alternativo que é insensível a abordagens terapêuticas baseadas na inibição da telomerase», explica Claus Azzalin, líder do grupo no iMM.

VII Workshop on Cancer Research Biological & Molecular Basis

i3S/Ipatimup, Meeting room 2, Porto Portugal

 

29 May - 01 June, 2017

 

See more informations here: https://www.ipatimup.pt/Site/ActivityView.aspx?ActivityId=2990

VII Workshop on Cancer Research Biological & Molecular Basis

i3S/Ipatimup, Meeting room 2, Porto Portugal

 

29 May - 01 June, 2017

 

See more informations here: https://www.ipatimup.pt/Site/ActivityView.aspx?ActivityId=2990

Spring Course in Hereditary Cancer Genetics

University Residential Centre of Bertinoro, Bertinoro, Italy

 

10 - 13 April, 2016

 

See more informations here: http://www.ceub.it/default.asp?id_c=510&id=436#.Vq-V609OfAV

Spring Course in Hereditary Cancer Genetics

University Residential Centre of Bertinoro, Bertinoro, Italy

 

10 - 13 April, 2016

 

See more informations here: http://www.ceub.it/default.asp?id_c=510&id=436#.Vq-V609OfAV