ASPIC

Primeiras evidências da importância da via RANKL-RANK em cancro da mama hormodependente

Ao longo dos últimos anos, esta equipa do IMM tem estudado a via RANKL-RANK, principal mecanismo regulador da remodelação óssea, e muito importante na terapêutica de doentes com metástases ósseas. Esta via de sinalização celular foi, mais recentemente, implicada na carcinogénese mamária controlada pela progesterona, estando sobretudo associada a mau prognóstico e cancro da mama triplo negativo.

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RANKL-RANK pathway

breast cancer

stemness

metastization

New epigenetic biomarkers for the detection of bladder cancer in urine

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Authors and affiliations:
Sara Monteiro-Reis (1), Ana Blanca (2), Joana Tedim-Moreira (1), Isa Carneiro (1,3), Diana Montezuma (1,3), Paula Monteiro (1,3), Jorge Oliveira (4), Luís Antunes (5), Rui Henrique (1,2,6), António Lopez-Beltran (7,8) e Carmen Jerónimo (1,6)

(1) Grupo de Epigenética e Biologia do Cancro – Centro de Investigação (CI-IPOP), Instituto Português de Oncologia do Porto Francisco Gentil EPE (IPO Porto), e Porto Comprehensive Cancer Center (P.CCC), Porto, Portugal;

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Novos biomarcadores epigenéticos para deteção de cancro da bexiga em urina

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Investigadores do Grupo de Epigenética e Biologia do Cancro do Centro de Investigação do IPO do Porto e da Universidade de Córdoba, em Espanha, publicaram recentemente na revista internacional Journal of Clinical Medicine os resultados de um dos seus mais recentes trabalhos, onde descrevem o desempenho de um novo teste não-invasivo que poderá ajudar na identificação de casos de cancro da bexiga numa população com outras patologias urinárias.

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Webinar - «Cancer Biology: From Basic To Translational Research»

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25 September, 2020

See more informations here: https://www.ligacontracancro.pt/cancer-biology-from-basic-to-translational-research/

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cancer research

Cancer Biology

Liga Portuguesa Contra o Cancro

ASPIC

Webinar - «Cancer Biology: From Basic To Translational Research»

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25 September, 2020

See more informations here: https://www.ligacontracancro.pt/cancer-biology-from-basic-to-translational-research/

Tags:

cancer research

Cancer Biology

Liga Portuguesa Contra o Cancro

ASPIC

First mouse model for HPV ‐related penile cancer

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Authors and Afilliations:

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Primeiro modelo murino para o cancro do pénis

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Uma equipa internacional de investigadores desenvolveu o primeiro modelo animal para estudar o cancro do pénis induzido pelo vírus do papiloma humano (HPV).

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Targeting STAT3 inhibits endocrine resistant stem cells in ER+ breast cancer

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Over the last 15 years my research work has been focused in understanding the molecular mechanisms that govern normal and breast cancer stem cells (CSCs). My ultimate goal has always been to translate basic discoveries to clinical applications that can in the long term directly impact on patient care and contribute to a reduction in breast cancer mortality. This work epitomizes this translational research idea because it was pivotal to establishing the grounds for a phase 2 clinical trial on metastatic breast cancer.

Tags:

breast cancer

stem cells

metastatic breast cancer

Bruno M. Simões

ASPIC

Targeting STAT3 inhibits endocrine resistant stem cells in ER+ breast cancer

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Over the last 15 years my research work has been focused in understanding the molecular mechanisms that govern normal and breast cancer stem cells (CSCs). My ultimate goal has always been to translate basic discoveries to clinical applications that can in the long term directly impact on patient care and contribute to a reduction in breast cancer mortality. This work epitomizes this translational research idea because it was pivotal to establishing the grounds for a phase 2 clinical trial on metastatic breast cancer.

Tags:

breast cancer

stem cells

metastatic breast cancer

Bruno M. Simões

ASPIC

Morphophenotypic Classification of Hepatocellular Carcinoma

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Authors and Affiliations:

Rui Caetano Oliveira,MD^1,2,3 & Ricardo Martins,MD^2,3,4,5,6 & Ana Margarida Abrantes,MSc, PhD^2,3 & Ângela Jesus, MSc¹ & Paulo Teixeira, MSc¹ & Carolina Canhoto, MD⁴ & Pedro Guerreiro, MD⁴ & Beatriz Costa, MD, PhD^3,4,5 & Mário Rui Silva, MD¹ & José Guilherme Tralhão, MD, PhD^4,5,6 & Maria Augusta Cipriano, MD¹