Presently, breast cancer constitutes the most prevalent cancer in women worldwide, and about 25% of the women with breast cancer also present type 2 diabetes mellitus (T2DM).The metabolic changes characteristic of T2DM have been associated to a higher incidence and progression, worst prognontics and response to therapy. However, the association between breast cancer and type 2 diabetes are complex and remain to be fully established.
The inflammatory status interferes with the cellular uptake of butyrate and folic acid, two nutrients with a role in colorectal cancer pathogenesis, by intestinal epitelial cells. The anti-inflammatory acetylsalicylic acid potentiates the anticarcinogenic effect of BT in Caco-2 cells by increasing its cellular uptake.
Mafalda R. Couto, M.D.1#, Pedro Gonçalves, Ph.D.1, 2#, Telmo A. Catarino, B.Sc.1, Fátima Martel, Ph.D.1
The inflammatory status interferes with the cellular uptake of butyrate and folic acid, two nutrients with a role in colorectal cancer pathogenesis, by intestinal epitelial cells. The anti-inflammatory acetylsalicylic acid potentiates the anticarcinogenic effect of BT in Caco-2 cells by increasing its cellular uptake.
Mafalda R. Couto, M.D.1#, Pedro Gonçalves, Ph.D.1, 2#, Telmo A. Catarino, B.Sc.1, Fátima Martel, Ph.D.1
