ASPIC

Vulnerabilidades genéticas do cancro da mama são alvo de uma abordagem inovadora baseada em vectores de terapia génica. Este trabalho que juntou equipas do iBET e do IPATIMUP é baseada em shRNA entregues por partículas de AAVs e demonstra a possibilidade de diminuir a velocidade de crescimento de tumores da mama do tipo basal através do silenciamento da proteína PSMA2 (Proteasome subunit alpha type-2). Embora preliminar, este estudo representa um primeiro passo no desenvolvimento de novas terapias para este tipo de cancro.

Autores e afiliações, 

In this work, the team led by Carla Cruz from the Health Sciences Research Centre of the University of Beira Interior (CICS-UBI) has developed a strategy for the selective delivery of an anticancer compound to cervical cancer cells, using AS1411 as vehicle. AS1411 aptamer is a guanine-rich oligonucleotide which binds and recognizes protein nucleolin that is overexpressed on the surface of cancer cells, showing anticancer activity on a variety of cancer cell types.

Authors and affiliations:

Bruno Silva(1), Richard Pentz(1), Ana Margarida Figueira(1), Rajika Arora(1), Yong Woo Lee(1), Charlotte Hodson(2), Harry Wischnewski(3), Andrew J. Deans(2,4), and Claus M. Azzalin(1)

(1)Instituto de Medicina Molecular João Lobo Antunes (iMM), Faculdade de Medicina da Universidade de Lisboa, Lisbon, 1649-028, Portugal

(2)Genome Stability Unit, St. Vincent’s Institute of Medical Research, Fitzroy, 3065, VIC, Australia

Authors and affiliations:
Cristina P.Matos, Zelal Adiguzel, Yasemin Yildizhan, Buse Cevatemre, Tugba Bagci Onderc, Ozge Cevik, Patrique Nunes, Liliana P. Ferreiraf, Maria Deus Carvalho Débora L. Campos, Fernando R. Pavan, João Costa Pessoa, Maria Helena Garcia, Ana Isabel Tomaz, Isabel Correia, Ceyda Acilan

Abstract:

Virtual event, Worldwide

23 - 24 March, 2020

See more informations here: https://www.eacr.org/conference/molecularpathology2021virtual?utm_source=confseriespage&utm_medium=web&utm_campaign=vMP21&utm_content=

Virtual event, Worldwide

23 - 24 March, 2021

See more informations here: https://www.eacr.org/conference/molecularpathology2021virtual?utm_source=confseriespage&utm_medium=web&utm_campaign=vMP21&utm_content=

Hyaluronic acid or hyaluronan is a biopolymer that accumulates in tumor microenvironments and around cancer cells. The accumulation is concomitant with changes of hyaluronan properties resulting in the generation of chains with different sizes. In this study, we mimic this peculiar tumor microenvironment and studied the response of gastric cancer cells. We selected two types of cells: AGS that have low expression of CD44 – a specific cellular receptor that recognize the hyaluronan and MKN45 with high CD44 expression.