ASPIC

i3S - Ipatimup, Porto, Portugal

28 November, 2017

See more informations here: https://www.ipatimup.pt/Site/ActivityView.aspx?ActivityId=3042
 

Authors and Affiliations:

Oriana Rainho Brás^1,2, Jean-Philippe Cointet³, Alberto Cambrosio⁴, Leonor David^2,5,6,7, João Arriscado Nunes^8,9, Fátima Cardoso^2,10, Carmen Jerónimo^2,11,12

A ASPIC publica este mês os primeiros resultados do projecto ReportCancer/CancerReport: Researching the dynamics and international positioning of the portuguese medical oncology community. Tendo por base a análise cientométrica das publicações portuguesas nas bases de dados Medline/PubMed e Web of knowledge, este estudo veio preencher uma enorme lacuna de conhecimento sobre a investigação em cancro em Portugal na segunda metade do século XX e início do século XXI.

Fine-needle aspiration (FNA) has high sensitivity and specificity in distinguishing benign from malignant thyroid lesions. However, in 5-20% of the cases belonging to the indeterminate cytology categories (follicular neoplasms and atypia of undetermined significance) it is not possible to discriminate between benign and malignant tumours. As a consequence of this limitation, patients with such diagnoses have to be submitted to diagnostic rather than to curative thyroid surgery.

Fine-needle aspiration (FNA) has high sensitivity and specificity in distinguishing benign from malignant thyroid lesions. However, in 5-20% of the cases belonging to the indeterminate cytology categories (follicular neoplasms and atypia of undetermined significance) it is not possible to discriminate between benign and malignant tumours. As a consequence of this limitation, patients with such diagnoses have to be submitted to diagnostic rather than to curative thyroid surgery.

Medullary thyroid carcinoma (MTC) is a rare tumor representing 5–10% of thyroid cancers, with a 10-year survival rate is about 50–75%. It arises from a particular thyroid cell type: the parafollicular C-cells of the thyroid which secrete calcitonin (CT). Serum CT is a very sensitive and specific method for diagnosing MTC, however, the potential role of calcitonin receptor (CTR) expression on tumor aggressiveness and prognosis remained to be explored.

O carcinoma medular da tiroide (CMT) é um tumor raro, representando cerca de 5-10% de todos os carcinomas da tiroide, com uma taxa de sobrevida livre de doença aos 10 anos de 50-75%. Este carcinoma provém de um tipo particular de células tiroideias, denominadas células C, produtoras de calcitonina (CT). Os níveis séricos de CT são um marcador de diagnóstico muito sensível e especifico dos CMT, no entanto, o potencial papel do recetor da calcitonina (RCT) relativamente à agressividade tumoral e prognóstico, permanece desconhecido.

Authors and Affiliations:

Gouveia MJ^1,2, Pakharukova MY^3,4, Laha T^5,6,7, Sripa B^5,6,7, Maksimova GA³, Rinaldi G⁸, Brindley PJ⁸, Mordvinov VA^3,9, Amaro T¹⁰, Santos LL¹⁰, Costa JMCD^1,11, Vale N^2,12.

¹ Center for the Study in Animal Science, ICETA, University of Porto, Rua de D. Manuel II, Apt 55142, 4051-401 Porto, Portugal.

Autores e Afiliações:

Gouveia MJ^1,2, Pakharukova MY^3,4, Laha T^5,6,7, Sripa B^5,6,7, Maksimova GA³, Rinaldi G⁸, Brindley PJ⁸, Mordvinov VA^3,9, Amaro T¹⁰, Santos LL¹⁰, Costa JMCD^1,11, Vale N^2,12.

¹ Center for the Study in Animal Science, ICETA, University of Porto, Rua de D. Manuel II, Apt 55142, 4051-401 Porto, Portugal.